well, first off, McAfee, please die.

Using this combo>> COMODO Firewall + ESET Nod32 AV will keep you completly safe and out of any internet harm. This combo has antivirus, spyware buster, and a firewall. As for the spyware, usually, spyware is hard copied on to sensitive dircetories in your PC. So your best bet to get everything clean would be to format. Listen to what i have to say and your machine will be brand new, clean of anything, and it will feel great. ::

First off, backup ANY important files, docs etc...

Then, grab your O/S disc, and the pop it in, and restart, make sure the CD boots.
Then use its feature to "Format" your hard drive.(This will completley wipe EVERYTHING off your hard drive. including the spyware and the trojan that most come with.

Next, go through the O/S installation.

Then, the first thing you want to do when your PC loads up nice and fresh, is go to downloads.com and download the Software i stated above.

Go through the installation for them all and then your computer will be totally safe and nice and clean and brand new feeling.

Then just put back all of the sensitive data that you backed up from before.

Wa-La! your computer is backdoor, trojan, spyware and malware or anything CLEAN! and now, since you have the software i recommended, you wont ever get anything bad again, unless someone shuts off all of it and downloads a trojan lol.

Follow this, and you will be set for another 3-4 years, when they come out with updates for everything lol.

Good luck!